Where To Buy Sentinel For Dogs

Where To Buy Sentinel For Dogs

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The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies. SENTINEL (milbemycin oxime/lufenuron) Flavor Tabs also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infection in dogs and puppies.

When treatment was initiated during the flea season, lufenuron tablets were effective in controlling flea infestations on dogs that completed the study. The mean flea count per lufenuron-treated dog was approximately 74 prior to treatment but had decreased to 4 after six monthly doses of lufenuron. A topical adulticide was used in the first eight weeks of the study to kill the pre-existing adult fleas.

Two studies in heartworm-infected dogs were conducted which demonstrated mild, transient hypersensitivity reactions in treated dogs with high microfilaremia counts (see Precautions for reactions observed). Safety studies in pregnant dogs demonstrated that high doses (1.5 mg/kg = 3X) of milbemycin oxime given in an exaggerated dosing regimen (daily from mating through weaning), resulted in measurable concentrations of the drug in milk. Puppies nursing these females which received exaggerated dosing regimens demonstrated milbemycin-related effects. These effects were directly attributable to the exaggerated experimental dosing regime. The product is normally intended for once-a-month administration only. Subsequent studies included using 3X daily from mating to one week before weaning and demonstrated no effects on the pregnant females or their litters. A second study where pregnant females were dosed once at 3X the monthly use rate either before, on the day of or shortly after whelping resulted in no effects on the puppies.

Some nursing puppies, at 2, 4, and 6 weeks of age, given greatly exaggerated oral doses of milbemycin oxime (9.6 mg/kg = 19X) exhibited signs typified by tremors, vocalization and ataxia. These effects were all transient and puppies returned to normal within 24 to 48 hours. No effects were observed in puppies given the recommended dose of milbemycin oxime (0.5 mg/kg). This product has not been tested in dogs less than 2.2 pounds in body weight.

A rising-dose safety study conducted in rough-coated collies manifested a clinical reaction consisting of ataxia, pyrexia and periodic recumbency in one of fourteen dogs treated with milbemycin oxime at 12.5 mg/kg (25X monthly use rate). Prior to receiving the 12.5 mg/kg dose (25X monthly use rate) on day 56 of the study, all animals had undergone an exaggerated dosing regimen consisting of 2.5 mg/kg milbemycin oxime (5X monthly use rate) on day 0, followed by 5.0 mg/kg (10X monthly use rate) on day 14 and 10.0 mg/kg (20X monthly use rate) on day 32. No adverse reactions were observed in any of the collies treated with this regimen up through the 10.0 mg/kg (20X monthly use rate) dose.

Four reproductive safety studies were conducted in breeding dogs with lufenuron tablets: two laboratory and two well-controlled clinical studies. In one of the laboratory studies, where lufenuron was administered to beagle dogs at doses equivalent to 90X (3X daily) the monthly recommended dose of 10 mg/kg, the ratio of gravid females to females mated was 8/8 or 100% in the control group and 6/9 or 67% in the lufenuron-treated group. The mean number of pups per litter was two animals higher in the treated versus control groups and the mean birth weights of pups from treated bitches in this study was lower than control groups.

These pups grew at a similar rate to control pups. There was a higher incidence of four clinical signs in the lufenuron-treated versus control group: nasal discharge, pulmonary congestion, diarrhea/dehydration and sluggishness. The incidence of these signs was transient and decreasing by the end of lactation. Results from three additional reproductive safety studies, one laboratory and two clinical field studies evaluating eleven breeds of dogs, did not demonstrated any adverse finding for the reproductive parameters measured including fertility, pup birth weights and pup clinical signs after administration of lufenuron up to 5X the recommended monthly use rate.

Data from analysis of milk from lactating animals treated with lufenuron tablets of 2X and 6X the recommended monthly use rate demonstrates that lufenuron concentrates in the milk of these dogs. The average milk: blood concentration ratio was approximately 60 (i.e., 60X higher drug concentrations in the milk compared to drug levels in the blood of treated bitches). Nursing puppies averaged 8-9 times higher blood concentrations of lufenuron compared to their dams.

This insert describes the concurrent use of SENTINEL (milbemycin oxime/lufenuron) Flavor Tabs and CAPSTAR (nitenpyram) Tablets for the management of fleas on dogs and puppies. Please read the insert contained in each package for complete information of the individual products prior to dispensing or dosing. The effects of Sentinel Flavor Tabs on heartworm disease and internal parasites are not described in this supplement.

Preventer Plus Flavor Tabs (milbemycin oxime + lufenuron) are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. Each tablet is formulated to provide a minimum of 0.23 mg/lb (0.5 mg/kg) body weight of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A4 and 20% A3 Milbemycin oxime is classified as a macrocyclic antihelminthic.

IndicationsPreventer Plus Flavor Tabs are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. Preventer Plus Flavor Tabs are indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworms) and Trichuris vulpis (whipworm) infections.

Preventer Plus Flavor Tabs are palatable and most dogs will consume the tablet when offered by the owner. As an alternative to direct dosing, the tablets can be hidden in food. Be certain the dog consumes the entire tablet. Administer Preventer Plus Flavor Tabs to dogs immediately after or in conjunction with a normal meal. Food is essential for adequate absorption of lufenuron. Watch the dog closely following administration to be sure the entire dose have been consumed

Preventer Plus Flavor Tabs must be administered monthly, preferably on the same date each month. Treatment may begin at any time of year. In geographic areas where mosquitoes and fleas are seasonal, the treatment schedule should begin one month prior to the expected onset and should continue until the end of mosquito and flea season. In areas with year-round infestations, treatment should continue through the entire year without interruption.

PrecautionsDo not use in puppies less than four weeks of age and less than two pounds of body weight. Prior to initiation of the Preventer Plus Flavor Tabs treatment program, dogs should be tested for existing heartworm infections. Infected dogs should be treated to remove adult heartworms and microfilariae prior to initiating treatment with Preventer Plus Flavor Tabs. Mild transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy, have been noted in some treated dogs carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.

Sentinel Flavor Tabs are formuled for dogs and puppies, four weeks of age and older, and two pounds body weightnor greater. T It is also formulated to help prevent and control flea populations, and for the treatment and control of adult roundworm, hookworm and whipworm infections. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.

The following adverse reactions have been reported in dogs alter giving milbemycin oxime orlufenuron: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia,convulsions, hypersalivation, and weakness.

Not all heartworm medicines provide the same spectrum of parasite protection. Sentinel Flavor Tabs are chewable tablets that protect dogs against fleas, heartworms, roundworms, hookworms, and whipworms. Sentinel Spectrum is a soft, beef and bacon flavored chew that adds tapeworm protection to offer the broadest coverage available.

SENTINEL SPECTRUM Chews (milbemycin oxime/lufenuron/praziquantel) gives protection against 6 different kinds of parasites including tapeworms. Powered by Lufenuron, SENTINEL SPECTRUM Chews stops flea eggsfrom hatching*, therefore controlling the development of flea populations. SENTINEL SPECTRUM offers protection against heartworms by eliminating the tissue stage of heartwormlarvae, while treating and controlling adult stages of tapeworms, hookworms, roundworms and whipworms. SENTINEL SPECTRUM does all this with convenient and effective once-a-month dosing with a soft beef and bacon flavored chew dogs love.

Comprehensive parasite protection is an essential part of canine overall health and well-being. The BRAVECTO product line, which are our extended duration flea and tick protection products, and the SENTINEL branded products, which control all common intestinal parasites, provide an attractive opportunity for broad-spectrum, year-round comprehensive internal and external parasite protection for dogs. These complementary products will cover the seven common, harmful parasites that affect dogs inside and out by preventing ticks and multiple stages of the flea lifecycle, including eggs and adult fleas, as well as treating and controlling all common intestinal parasites, including roundworms, hookworms, whipworms and tapeworms and preventing heartworm disease. 59ce067264

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